Lightning have made three starting changes from the side that beat Glasgow 31-19 last weekend.
Flanker Lily Terry joins captain Bryonie King and Catrin Stewart in the back row, with Gwennan Hopkins ruled out with a calf strain.
Prop Cana Williams starts with Maisie Davies and Molly Wakely in the front row, while Paige Jones and Alaw Pyrs are named as locks.
Courtney Greenway joins Jenny Hesketh and Caitlin Lewis in the back line.
Kelsie Webster and Molly Anderson-Thomas continue their centre partnership, as do half-backs Sian Jones and Carys Hughes.
“We are under no illusions of the task ahead of us against Wolfhounds, a side full of Irish internationals, but we are at home and shown we can be competitive at this level,” said Lightning head coach Catrina Nicholas-McLaughlin.
“With two games to go in the Celtic Challenge, it’s about us and what we want to achieve, and we should take confidence from the way we have played so far in the competition.”