Holland was in tears as she was helped off with Wilkinson describing her efforts as “excellent”.
The Wales boss added: “She gives everything and puts her body on the line. We hope it is just one of those that hurt a lot. Fingers crossed that is what it will be.”
Wilkinson added: “I saw the tackle quickly on my iPad, to me it looked like two women fully committed to a tackle.
“She was obviously in a lot of pain and discomfort.”
Former Wales international Nia Jones told BBC Match of the Day Wales that Holland’s injury overshadowed the whole game.
“I am sure Rhian Wilkinson will say there’s plenty to take from that game, but it’s really difficult to look beyond what happened to Ceri Holland,” she said.
“We are all hoping it’s not as bad as it looked.”
Wales international Sophie Ingle, who is currently sidelined after having anterior cruciate ligament (ACL) surgery, says Holland is a vital component in the Wales side.
“She is such a key player for us. She’s on the trajectory of being really strong and always being a starter,” Ingle told Match of the Day Wales.
“It didn’t look nice. It was contact. I didn’t really see a twist or anything.
“Sometimes it is better if it’s straight contact, but the fact she was upset and stayed down is not like her. She usually gets up pretty much straight away.”