Summer recruits Ellis Mee and Blair Murray make competitive debuts on the wings while hooker Marnus van der Merwe and lock Max Douglas are new faces in the pack.
Wales tight-head props Henry Thomas and Harri O’Connor are ruled out by injury along with new loose-head Alec Hepburn and lock Sam Lousi.
Scarlets finished 13th last season amid Welsh rugby’s well-documented financial issues with only five league wins.
Only two of those successes came from the first half of 2023-24.
Benetton reached the play-offs as they enhanced a growing reputation in the competition.
“It is important we start this first block well,” said Scarlets head coach Peel.
“Going to Treviso is a tough start against a combative side who have some real quality in their group, but we have prepared well and I’m excited to see how we go, particularly some of the younger boys like Macs Page and Ellis Mee, who have shown up well in pre-season.”
Benetton boss Marco Bortolami acknowledged his side’s progress has brought fresh challenges and a change of mindset.
“I am pleased with the progression of the team, but the challenge is to keep improving and keep the ambition to beat the biggest teams on the biggest stages,” said Bortolami.
“We are still building our winning mentality and I feel the players are in the right mindset.
“The underdog tag we had in previous years is going to be smaller and smaller.”