Wissa, who joined Brentford in August 2021 from Lorient, scored 19 Premier League goals last season as he helped the Bees finish 10th in the top flight.
“[I’m] very clear on the situation. As a head coach, I want Yoane in the building, to be a part of the first-team and the squad. I see that moving forwards but I am very understanding of his situation,” added Andrews.
“I have a very good relationship with him, and that will persist, but we have to focus on the players who are ready to play and perform on Sunday and I don’t think Yoane’s in that space.
“For Yoane on Sunday, he won’t be involved.”
Andrews took over at Brentford this summer following the departure of former boss Thomas Frank to Tottenham.
The Bees have lost forward Bryan Mbeumo to Manchester United, midfielder Christian Norgaard to Arsenal and keeper Mark Flekken to Bayer Leverkusen.
Their signings include England midfielder Jordan Henderson, Republic of Ireland keeper Caoimhin Kelleher and Dutch attacking midfielder Antoni Milambo.
“The only one who really disrupts an ideal preparation is the Yoane Wissa situation,” added Andrews.
“It is ideal? No, it’s not.
“Would the players like him to be part of the squad? Of course they would.”
