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World number one Novak Djokovic suffered a shock loss in three sets to Italian Lorenzo Musetti in the third round at the Monte Carlo Masters.<\/span><\/p>\n Djokovic, 35, won the opening set but eventually lost 4-6 7-5 6-4 in a match interrupted by a one hour rain delay.<\/span><\/p>\n<\/div>\n It marked the biggest win of Musetti’s career and he will play compatriot <\/span>Jannik Sinner <\/strong>in the quarter-finals.<\/span><\/p>\n “I am struggling not to cry,” Musetti said. “It is an emotional win because it was a really long match.”<\/span><\/p>\n The 16th seed added: “I am really proud of myself and I can see on the screen, I am struggling not to cry because it is a dream for me.”<\/span><\/p>\n Serbia’s 22-time Grand Slam champion Djokovic said he did not feel the defeat was “catastrophic” but added he felt “terrible” after exiting the tournament.<\/span><\/p>\n “I don’t think it’s catastrophic, but my feeling is bad right now because I lost the match,” Djokovic said.<\/span><\/p>\n “Well, [my] feeling is terrible after playing like this, honestly,” he added. “But congrats to him. He stayed tough in important moments, and that’s it. That’s all I can say.”<\/span><\/p>\n Two-time champion Djokovic, playing his first tournament since Dubai in early March, saw his serve broken eight times by world number 21 Musetti during the two-hour 54-minute match. He had lost serve just 17 times in his 17 previous matches this year.<\/span><\/p>\n Musetti’s reward for battling back against the world’s top-ranked player is a last-eight meeting with Sinner, who came back from a set and match point down to beat Hubert Hurkacz.<\/span><\/p>\n Seventh seed Sinner, a quarter-finalist in Monaco last year, beat the Pole 3-6 7-6 (8-6) 6-1.<\/span><\/p>\n With eight-time Olympic champion sprinter Usain Bolt present on the fifth day in Monte Carlo, Sinner rallied from the brink of defeat to overcome a fading Hurkacz, who conceded the match on a double fault.<\/span><\/p>\n Elsewhere, Miami Open champion <\/span>Daniil Medvedev<\/strong> saved two match points before winning a third set tie-break in a thrilling victory over former world number two <\/span>Alexander Zverev<\/strong>.<\/span><\/p>\n Third seed Medvedev, who plays Danish sixth seed <\/span>Holger Rune<\/strong> next after Italian Matteo Berrettini’s withdrew due to injury, fought back to win a dramatic match 3-6 7-5 7-6 (9-7).<\/span><\/p>\n German Zverev served for the match when leading 5-4 in the second and third sets, and failed to take two match points in the deciding tie-break, before Medvedev clinched victory with three successive points.<\/span><\/p>\n Defending champion <\/span>Stefanos Tsitsipas<\/strong> beat unseeded Chilean Nicolas Jarry 6-3 6-4 in his last-16 match.<\/span><\/p>\n However, fourth seed Casper Ruud was stunned by German qualifier <\/span>Jan-Lennard Struff<\/strong> earlier on Thursday.<\/span><\/p>\n