Tottenham have sent England midfielder Harry Winks to Sampdoria and Spain left-back Sergio Reguilon to Atletico Madrid on season-long loan deals.
Winks, 26, has spent his entire career with Spurs, playing 203 times and scoring five goals, as well as winning 10 caps for England.
Reguilon, 25, joined Spurs for an undisclosed fee from Real Madrid in the summer of 2020.
He made 25 Premier League appearances for the club last season.
But he has not featured this term and underwent groin surgery last week.
Atletico said the player – who had been a target for Fulham and Lazio – would continue his rehabilitation in Spain.
Earlier this week Atletico sent their Brazilian international left-back, Renan Lodi, on loan to Nottingham Forest.
